Article Sidebar
Published:
Jan 21, 2025Keywords:
Article Details
Copyright of articles published shall reside exclusively with the Faculty of Pharmaceutical Sciences, University of Jos.
DECLARATION & COPYRIGHT TRANSFER
I/We the undersigned author(s) of article entitled
…………………………………………………………………………………………………………………
…………………………………………………………………………………………………………………
Declare as follows:
- The manuscript submitted to Journal of Pharmacy & Bioresources is original and has not been and will be published, whole or in part, in print or electronic format, in any other journal. It is also not being currently considered for publication in any journal.
- The submitted manuscript is a joint decision of all the coauthors.
- Each author has participated sufficiently in the work to warrant his or her inclusion in the list of authors. To this end, each author takes responsibility for appropriate portions of the manuscript.
- Authors have obtained necessary approval to carry out the experiments on animals and human subjects. Approval certificates will be furnished, if required by publishers or editors of the journal.
- Authors do not have any conflict of interest (financial or otherwise) other than those declared.
- If the manuscript is accepted for publication, the authors transfer and assign copyright of the article referenced above to Journal of Pharmacy and Bioresources.
Name & Signature of authors
1. 2.
- 4.
- 6.
- 8.
Corresponding authors name address, affiliation and email:
Main Article Content
In vitro antioxidant and toxicity studies of Sorindeia warneckei Engl. (Anacardiaceae) stem methanol extract in laboratory animals
Abstract
Sorindeia warneckei (SW) Engl. (Anacardiaceae) is a plant of medicinal and economic significance. Its edible fruits are used in medicinal baths and stems as traditional toothbrushes. This study evaluates the antioxidant activity and safety profile of SW stem extract. Antioxidant activity was assessed using the diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Acute and sub-acute toxicity tests were performed following the protocol described by the Organization for Economic Cooperation and Development (OECD). The methanol extract of SW was rich in phytochemicals, with total phenolic and flavonoid contents measured at 149.64 ± 0.50 mg/g rutin equivalent and 172.097 ± 0.28 mg/g gallic acid equivalent respectively. SW demonstrated dose-dependent antioxidant activity (IC50
= 0.0246 mg/mL), comparable to ascorbic acid (IC50 = 0.0195 mg/mL). Acute toxicity studies indicated a lethal dose (LD50) > 2000 mg/mL. Haematological parameters were not adversely affected. However, certain biochemical markers exhibited significant alterations (p<0.05) following 28 days of treatment. Histological analysis revealed structural changes in renal and hepatic tissues, including hepatocyte hyperpigmentation and disorganization of the renal parenchyma. The findings highlight SW stem methanol extract's antioxidant potential but suggest caution regarding prolonged use due to signs of toxicity.
