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Jan 21, 2025Keywords:
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Main Article Content
Quality assessment of five brands of ascorbic acid tablets marketed in Ogun state, Nigeria
Abstract
Ascorbic acid (vitamin C), a water-soluble vitamin, is an essential nutrient that plays a crucial role in the body's antioxidant defences. Since the body cannot synthesize it, ascorbic acid must be obtained through either dietary sources or supplements. The aim of this study was to assess the quality and physicochemical properties of five different brands of ascorbic acid commonly sold in several pharmacy outlets in Ogun State. The brands were analysed for their uniformity of weight, hardness, friability and disintegration time using official methods, quantitative analysis was done using dissolution test and high-performance liquid chromatography (HPLC). One out of the five brands (20%) passed the weight uniformity test ranging between 282.7 mg to 364.8 mg, four (80 %) of the five brands passed the hardness test and were within 1.5 and 6.0 KgF. All five brands passed the friability test, disintegration test and
dissolution test and were within 0.0172 - 0.5691%, 0.36 - 13.52 mins and 96 - 103% respectively. The amount of API in each brand ranging from 97.25% to 103.07% were within official specifications when assayed with HPLC. This study elucidates the need for regular post market surveillance of medications to ensure the safety of consumers.
