Article Sidebar
Published:
Dec 5, 2018DOI:
10.4314/jpb.v15i2.11Keywords:
Article Details
Copyright of articles published shall reside exclusively with the Faculty of Pharmaceutical Sciences, University of Jos.
DECLARATION & COPYRIGHT TRANSFER
I/We the undersigned author(s) of article entitled
…………………………………………………………………………………………………………………
…………………………………………………………………………………………………………………
Declare as follows:
- The manuscript submitted to Journal of Pharmacy & Bioresources is original and has not been and will be published, whole or in part, in print or electronic format, in any other journal. It is also not being currently considered for publication in any journal.
- The submitted manuscript is a joint decision of all the coauthors.
- Each author has participated sufficiently in the work to warrant his or her inclusion in the list of authors. To this end, each author takes responsibility for appropriate portions of the manuscript.
- Authors have obtained necessary approval to carry out the experiments on animals and human subjects. Approval certificates will be furnished, if required by publishers or editors of the journal.
- Authors do not have any conflict of interest (financial or otherwise) other than those declared.
- If the manuscript is accepted for publication, the authors transfer and assign copyright of the article referenced above to Journal of Pharmacy and Bioresources.
Name & Signature of authors
1. 2.
- 4.
- 6.
- 8.
Corresponding authors name address, affiliation and email:
Main Article Content
Effect of aqueous extract of the aerial parts of Caralluma dalzielii N. E. Brown on the testosterone levels of male Wistar rats
Abstract
The aqueous extract of the aerial parts of Caralluma dalzielii (family Asclepiadaceae) has been used traditionally for the treatment of many ailments including infertility, convulsion, stomach problems and as aphrodisiac. The aim of the study was to evaluate the effect of the extract on testosterone level in male Wistar rats. Male Wistar rats were allotted into four groups of five rats each. Three doses of the extract (150, 300 and 600 mg/kg) and one distilled water control group were used for the assessment. The administration was done orally in all groups for 28 days. On the 29th day, blood samples were withdrawn via cardiac puncture for testosterone level assay. The testes were excised and fixed in Bouin’s solution for histopathological study. There was a significant (p<0.001 at 300 mg/g and p<0.05 at 150 and 600 mg/kg) rise in testosterone level among the test groups compared to the control. Histopathological examination showed no distortion in the testicular tissues. In conclusion, the extract of Caralluma dalzielii caused an increase in testosterone level which may be responsible for its use as an aphrodisiac in the traditional setting.
Keywords: Caralluma dalzielii, testosterone, testis, Wistar rats, aphrodisiac
