Article Sidebar
Published:
Dec 5, 2018DOI:
10.4314/jpb.v15i2.8Keywords:
Article Details
Copyright of articles published shall reside exclusively with the Faculty of Pharmaceutical Sciences, University of Jos.
DECLARATION & COPYRIGHT TRANSFER
I/We the undersigned author(s) of article entitled
…………………………………………………………………………………………………………………
…………………………………………………………………………………………………………………
Declare as follows:
- The manuscript submitted to Journal of Pharmacy & Bioresources is original and has not been and will be published, whole or in part, in print or electronic format, in any other journal. It is also not being currently considered for publication in any journal.
- The submitted manuscript is a joint decision of all the coauthors.
- Each author has participated sufficiently in the work to warrant his or her inclusion in the list of authors. To this end, each author takes responsibility for appropriate portions of the manuscript.
- Authors have obtained necessary approval to carry out the experiments on animals and human subjects. Approval certificates will be furnished, if required by publishers or editors of the journal.
- Authors do not have any conflict of interest (financial or otherwise) other than those declared.
- If the manuscript is accepted for publication, the authors transfer and assign copyright of the article referenced above to Journal of Pharmacy and Bioresources.
Name & Signature of authors
1. 2.
- 4.
- 6.
- 8.
Corresponding authors name address, affiliation and email:
Main Article Content
Synthesis of long chain lipid amides and their analgesic properties
Abstract
Long chain lipid amides isolated from animal tissues are known to have analgesic and anti-inflammatory properties. The synthesis of analogues of such lipid amides of biological origin was designed and carried out. The analgesic properties of some of the synthesized molecules were also carried out. Condensation reaction involving palmitoyl chloride and primary amino compounds was carried out to produce the desired compounds. Analgesic properties were investigated using acetic acid induced writhing and hot plate models. The synthetic procedure yielded the desired products in good quantity. There was a dose dependent analgesic activity of the products tested. These simple organic molecules, which show promising analgesic properties, could be developed into useful drugs that could be used as effective pain relievers.
Keywords: Benzyl palmitoylamide, propyl palmitoylamide, acetic acid induced writhing, hot plate model
