Extraction, characterization and evaluation of the binding property of Irvingia gabonensis seed gum in paracetamol tablet

Abstract

This research was conducted to extract, purify, and investigate the physiochemical properties of Irvingia gabonensis seed gum (IGG) and to evaluate it binding property in paracetamol tablet. The Irvingia gabonensis seeds were crushed and dispersed in hot water (80˚C). IGG was extracted with 95% ethanol and it was defatted using Petroleum ether. The physico-mechanical properties of IGG were evaluated using parameters such as flow rate, angle of repose, bulk and tapped density, Carr’s compressibility index, flow rate. IGG was granulated with other excipients and paracetamol powder using mixture of isopropanol and water (2:1) as granulating solvent. The granule size distribution revealed size and compactness in the following order: Acacia gum > IGG > Gelatin, and average granule size for the three set of batches were found to be 500 μm. The tablets were evaluated using the parameters: friability, disintegration time, weight uniformity and thickness, tablet hardness. The results obtained for crushing strength, friability, and disintegration time for F7 and F8 (having 7.5 and 10 %w/v IGG as binder) were: 54 N and 60 N, 0.12 % and 0.19 %, 27.00 and 29.10 min., respectively. F3and F4 (7.5 and 10 %w/v acacia gum as binder) 45 and 47 N, 0.1 and 0.13 %, 21.30 and 24.15 min., respectively; F11 and F12 (7.5 and 10 % w/v gelatin as binder) 100 and 110 N, 0.02 and 0.04 %, 45 and 60 min., respectively. In conclusion, at 7.5 and 10 %w/v, IGG proved to be a better binder than acacia in paracetamol tablets.

Keywords:  Irvingia gabonensis; Seed gum; Tablet binder; Wet granulation; Natural polymer