Article Sidebar
Published:
Jun 24, 2016DOI:
10.4314/jpb.v13i1.7Keywords:
Article Details
Copyright of articles published shall reside exclusively with the Faculty of Pharmaceutical Sciences, University of Jos.
DECLARATION & COPYRIGHT TRANSFER
I/We the undersigned author(s) of article entitled
…………………………………………………………………………………………………………………
…………………………………………………………………………………………………………………
Declare as follows:
- The manuscript submitted to Journal of Pharmacy & Bioresources is original and has not been and will be published, whole or in part, in print or electronic format, in any other journal. It is also not being currently considered for publication in any journal.
- The submitted manuscript is a joint decision of all the coauthors.
- Each author has participated sufficiently in the work to warrant his or her inclusion in the list of authors. To this end, each author takes responsibility for appropriate portions of the manuscript.
- Authors have obtained necessary approval to carry out the experiments on animals and human subjects. Approval certificates will be furnished, if required by publishers or editors of the journal.
- Authors do not have any conflict of interest (financial or otherwise) other than those declared.
- If the manuscript is accepted for publication, the authors transfer and assign copyright of the article referenced above to Journal of Pharmacy and Bioresources.
Name & Signature of authors
1. 2.
- 4.
- 6.
- 8.
Corresponding authors name address, affiliation and email:
Main Article Content
Antidiabetic effect of Crossopteryx febrifuga methanolic leaf extract in alloxan induced diabetic rats
Abstract
Diabetes mellitus is a potentially morbid condition with high prevalence worldwide thus the disease constitutes a major health concern. Presently, it is an incurable metabolic disorder which affects about 2.8% of the global population. This study, investigate the antidiabetic effect of methanolic leaf extract of Crossopteryx febrifuga in alloxan induced diabetes rats. The plant was found to be safe with an LD 50 value of 5000mg/kg and phytochemical screening reveal the presence of flavonoids, tannins, saponins and carbohydrates. The plant significantly decreased blood glucose level at p < 0.05 from 139 to 83 mg/dl but body weight of treated rat and control slightly increased significantly after seven days of administration of the extract. The result from this study shows possible beneficial effects of Crossopteryx febrifuga in the management of diabetes.
Keywords: Diabetes mellitus; Crossopteryx febrifuga; Alloxan; Blood glucose; Diabetic rats
