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Main Article Content
Quantitative analysis of some brands of chloroquine tablets marketed in Maiduguri using spectrophotometric and high performance liquid chromatographic methods
Abstract
The experiment involves analysis of chloroquine using ultra violet spectrophotometer in the ultraviolet range (200- 400nm) and high performance liquid chromatography(HPLC) in which the samples were dissolved in various solvents and their various absorbance, peak area at various wavelength were determined and compared with that of the standard, wavelength of maximum absorbance at 331nm for chloroquine. Percentage and milligram content for each sample was determined so as to note if it was within the acceptable range of (92.5-107.5%) for chloroquine. For those that passed the test or if it was below or above the range for samples that are substandard or highly concentrated. The samples’ absorbance and peak area was used along side with the standard absorbance and peak area to calculate the percentage content of each sample. It was observed that of the six samples of chloroquine tablet, none passed the test using UV spectrophotometer while Dana chloroquine with 98.7%, Evans chloroquine 107.3% and Palquine 106.4% passed using HPLC.
Keywords: Chloroquine Tablet, UV, HPLC
