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Published:
Jul 8, 2014DOI:
10.4314/jpb.v10i2.3Keywords:
Article Details
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Main Article Content
Comparison of antimicrobial activity of six 5-amino tetrazole Schiff bases with their corresponding oxazepine derivatives
Abstract
Six novel five-amino tetrazole Schiff bases were synthesized by the condensation reaction of 5H–tetrazol-5-amine with three substituted aldehydes and three corresponding ketones, alongside their corresponding oxazepine derivatives by the reaction of the different five-amino tetrazole Schiff bases with furan-2,5-dione (maleic anhydride). The five-amino tetrazole Schiff bases have a wider range of percentage yield (17% - 87%) than their oxazepine derivatives which range from 17.98% to 53.68%. The detailed chemical and spectroscopic analyses are discussed. The prepared tetrazole Schiff bases and their corresponding oxazepine derivatives showed significantly different biological activities against two types of bacteria and fungi. The two bacteria used were Staphylococcus aureus (Gram positive) and Pseudomonas aeruginosa (Gram negative) while the fungus used is Candida albicans.
Keywords: Schiff base, Oxazepine, Antimicrobial screening
