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Published:
Jul 8, 2014DOI:
10.4314/jpb.v10i2.2Keywords:
Article Details
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Main Article Content
Teratogenic assessment of ‘Winniecure’ in pregnant Wistar rats
Abstract
The study to determine the possible teratogenicity of Winniecure (a multicomponent herbal remedy) was carried out on pregnant female Wistar rats. A single dose of Winniecure suspension (8.4mg/kg) was administered intraperitoneally to 3 groups of pregnant Wistar rats on the 1st, 2nd and 3rd weeks of gestation, respectively. The control group received corresponding dose of normal saline during gestation. On day 20 of gestation, the litter of each rat was delivered by hysterectomy and examined for gross anomalies. The colour, activity, weight and length of the litters were also assessed and recorded. The results showed no teratogenic effect of the single dose of Winniecure, during any of the trimesters of pregnancy. However, it is possible that multiple and/or higher doses of Winniecure, administered in the 1st week of gestation may produce teratogenicity as anomalies or abortions.
Keywords: Winniecure; Teratogenicity, Wistar rats; Litter; Gestation
