Deposition of terbutaline sulphate and salbutamol sulphate from multiple dose dry power inhaler device

Abstract

The inhaler device is as important as the powder formulation for the successful development of dry powder inhalation products. As a result of current focus on tightening regulatory requirements, it is imperative that reproducibility of the metered dose of drug must be ensured during the formulation, packaging and use. We developed a dry powder inhalation package consisting of drug formulation and design of device (KCHALER, KCL Enterprises) for Phase 1 and Phase 2 Clinical studies. In this report, we present data on dose reproducibility obtained with the KCHALER device and the effect of type of mouthpiece on the KCHALER device on terbutaline and salbutamol deposition in the Twin Impinger BP.

Keywords: KCHALER^TM device, dose reproducibility, mouthpiece, drug deposition Twin Impinger BP

Journal of Pharmaceutical and Allied Sciences, Vol. 7 No. 3 (2010)