In vitro permeation studies of diclofenac diethylamine from newly developed oleogel bases

Abstract

The study was designed to investigate the feasibility of developing a transdermal drug dosage form of diclofenac diethylamine (DDA). The in vitro release and diffusion characteristics of  DDA from two dermatological oleogel bases were studied using full thickness skin from the abdominal hairless surface of rabbit, as the diffusion barriers. The bases included, sesame oil with colloidal silicon dioxide (CSD-SO) oleogel and light liquid paraffin with colloidal silicon dioxide (CSD-LP) oleogel both containing 1.16 % w/w DDA. Results of the diffusion studies show that the CSD-SO oleogel exhibited the optimum drug release. The data also revealed that CSD-SO oleogel gave higher diffusion and permeability coefficient values when compared to (CSD-LP) oleogel and these results correlated well with those of drug release.

Keywords: Diclofenac diethylamine , skin permeability, oleogels, drug release, transdermal

Journal of Pharmaceutical and Allied Sciences, Vol. 7 No. 3 (2010)