Antimicrobial properties of metronidazole nanoemulsion

Abstract

Metronidazole nanoemulsion was prepared with different ratios of surfactant (Tween 80) to co- surfactant (propylene glycol) using High  Pressure Homogenization. The nanoemulsion was characterized using SEM, and Particle Size Analysis. The density, viscosity, pH, and  stability were also determined. The microbial activities of the metronidazole nanoemulsion were tested on two Gram positive and two  Gram negative test microorganisms, and the inhibition zone diameters were measured. The results obtained revealed that the  metronidazole nanoemulsion displayed good antibacterial activity against these test microorganisms. SEM analysis indicated the  formation of well dispersed uniform spherical particles.