Ameliorative effects of lauric (dodecanoic) acid on adipokines and insulin levels in experimental diabetes produced by streptozotocin intensified with high-fat diet

Abstract

This study aimed to investigate ameliorative effects of lauric (Dodecanoic) acid on adipokines and insulin levels in experimental diabetes produced by streptozotocin intensified with high-fat diet Lauric acid enhances insulin levels in experimental diabetes produced by streptozotocin intensified with a high-fat diet. The animals were randomly divided into six groups, each of five animals: Group 1 = serves as normal control, Group 2 = lauric acid 125 mg/kg only, Group 3 = lauric acid 250 mg/kg only, Group 4 = high fat diet only, Group 5 = high fat diet + lauric acid 125 mg/kg, Group 6 = high fat diet + lauric acid 250 mg/kg. The preparations were administered for 8 weeks of the treatment protocol. At the end of the experiment, blood samples were evaluated for serum concentrations of biochemical entities (adiponectin, leptin and insulin). Serum adiponectin significantly (P < 0.05) increased in the high-fat diet administered different doses of lauric acid as compared to the group fed on a high-fat diet only. Leptin and insulin significantly (P <0.05) decreased in high-fat diet groups co-administered with both lauric acid and high-fat diet, compared with the group fed on a high-fat diet only. In conclusion, the increase in adiponectin level and decrease in leptin and insulin level following lauric (Dodecanoic) acid administration elucidated the therapeutic potential of lauric (Dodecanoic) acid, despite high fat diet consumption.