Evaluation of the controlled release potential of

Abstract

The suitability of A. digitata mucilage (ADM) as an excipient in the formulation of matrix tablets, the mechanism and kinetics of drug delivery were studied. Aminophyline was the prototype drug while these properties were compared to those of HPMC and Cp. ADM was used at concentration levels of 10, 15 and 30% of the tablet weight while HPMC and Cp were used at 30% concentration. The tablet friability, attrition and dissolution characteristics were evaluated. All the tablets formulated showed good physical properties. The ADM matrix tablets showed similar drug release and attrition pattern to those of Cp in both SIF and SGF. Generally the drug release retardation efficiency of the ADM tablets at equal polymer concentration was higher than those of Cp but less than that of HPMC in both SGF and SIF. The mechanism of release of aminophyline from ADM as in Cp and HPMC was by diffusion.

Keywords: Adansonia digitata mucilage; Carbopol; Hydroxymethylpropylcellulose; Matrix tablets

JOPAT Vol. 12 2007: pp. 22-30