Hematological, biochemical and histological evaluation of sub-chronic administration of ethanol leaf extract of Canscora decussate on kidney and stomach of Wistar rats

Abstract

Canscora decussate is traditionally believe to relieve renal and gastro intestinal tract disorder. Ethanol leaf extract of Canscora decussate was tested for chronic effect on Kidney and Stomach of wistar rats by evaluating the hematological, biochemical and histological parameters of these organs. The study was done by grouping the animals in to 4 groups with each group receiving different concentrations of the extract (100-400mg/kg) respectively for 28 days, physical observation of the rats was carried out every day of the study. Mean corpuscular volume, and red blood cell levels decreased significantly (P≤0.05) at 200 and 400 mg/kg doses, but not basophiles, neutrophils, eosinophils, or platelets. There was no significant change (p≤0.05) in serum sodium chloride, potassium creatinine and urea when compared to the control group at all doses delivered. Slight lymphocyte hyperplasia with normal kidney histology architecture observed at all doses and the control (10 ml/kg). Canscora decussateis relatively safe for use as it does not possess danger against traditional use.