COVID ORGANICS as herbal remedy for treatment of COVID-19: Evaluation of oral safety, antitussive, expectorant and antipyretic activities

Abstract

COVID ORGANICS (CVO) is a herbal remedy developed for treatment of COVID-19. This study was aimed to verify oral safety and efficacy the product against symptomatic presentation of COVID-19 infection. Its acute oral safety was investigated using the limit test (2000 mg/kg, p.o.) in mice, while the sub-chronic toxicity was investigated by 28 days daily administration of CVO (1000 mg/kg) in rats. The antitussive, mucosecretolytic and antipyretic activities of three dose levels of the product (50, 200 and 800 mg/kg, p.o.) were evaluated using standard models in rats and mice. Results showed that the product was safe, exhibited suboptimal antitussive, expectorant activities and reduced pyrexia at higher doses (200 and 800 mg/kg, p.o.).