Logistic Analysis Of Acute Toxicity Of Hunteria Umbellata Extract In Mice Through Intraperitoneal Route

Abstract

In this paper, we analyse the acute toxicity of Hunteria umbellata, a herbal medicinal plant, in mice in Nigeria using the logistic model. Hunteria umbellata is a plant with therapeutic potentials in the treatment of various diseases that include yaws, peptic ulcers, diabetes, piles, infertility and inflammation. Data on the acute toxicity of seeds extract of Hunteria umbellata is obtained via intraperitoneal route and analysed. The median lethal dose is determined and found to be 1.5979g/kg of body weight with confidence limits as [1.4335g/kg, 1.7811g/kg]. This shows slight toxicity of Hunteria umbellata and its toxicity at a high dose on acute exposure should be put into consideration when it is used as treatment for these diseases.

Keywords: Hunteria umbellata, logistic model, acute toxicity, median lethal dose (LD50)

Journal of the Nigerian Association of Mathematical Physics, Volume 19 (November, 2011), pp 135 – 138