Effect of Dennettia Tripetela (MMIMI) Seed intake on the IOP of Normotensive Emmetropic Nigerian Igbos

Abstract

Dennetia Tripetala is a well known forest fruit from the family annonacea and spicy indigenous plant and has been found to contain lots ofminerals, vitamins, alkaloids and trace elementswhich are ofmedicinal importance. The study was aimed at investigating the effect of DennetIaTripetala (D. Tripetala) on the intraocular pressure of normotensive emmetropic Igbos of Eastern Nigeria. Forty volunteers (meanage 23.36±3.60yrs) were usedfor the study.The 10P of each subject was measured pre and post ingestion of 0.75g of seed at 30mins interval for 120 minutes.The findings showed peak reduction of IOP after 60mins (11.20mmHg, representing25.64% reduction) of consumption and increased towards baseline (15.6mmhg). Results also showed slight reduction of IOP at the 90mins (12.96mmHg induced value) and 120mins (14.40mmHg induced value) post ingestion.The peakeffect of D. Tripetala was found to be statisticallysignificant (p>0.05). It is recommended that intake of seed be encouraged especially among glaucomatous individuals.

Keywords: Dennetia Tripetala flavonoids, oleoresins, intraocular pressure, glaucomas