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Neutrophil Segmentation Index Anomaly in Acquired Immunodeficiency Syndrome
Abstract
Neutrophil lobe count was conducted on the blood films of 262 patients with the Acquired Immunodeficiency Syndrome Virus (AIDS) and 204 Human Immunodeficiency Virus (HIV) antibody-negative apparently healthy controls.
The count for each group was evaluated for neutrophil segmentation index by standard method. The results for hypersegmentation index were 18.7% for the control and 85.9% for the patients with AIDS. The difference in the mean results between the two groups was statistically significant (p<0.05). It is suggested that the direct effect of HIV infection, presence of other possible secondary infections and accompanying pathologic processes may account for the segmentation anomaly in patients with AIDS. The anomaly could have negative implications for neutrophil competence in response to unusual
opportunistic infection in patients with AIDS.
The count for each group was evaluated for neutrophil segmentation index by standard method. The results for hypersegmentation index were 18.7% for the control and 85.9% for the patients with AIDS. The difference in the mean results between the two groups was statistically significant (p<0.05). It is suggested that the direct effect of HIV infection, presence of other possible secondary infections and accompanying pathologic processes may account for the segmentation anomaly in patients with AIDS. The anomaly could have negative implications for neutrophil competence in response to unusual
opportunistic infection in patients with AIDS.
