Investigation of the Effect of Aqeous Mistletoe Leaf Extract on Glucose and Cholesterol Levels in Alloxan-Induced Diabetic Rabbits

Abstract

Aqueous leaf extract of the mistletoe was investigated for hypoglycaemic and hypocholesterolaemic effect in diabetic rabbits. Diabetes mellitus was induced in rabbits in groups I-II by a single intraperitoneal injection of alloxan monohydrate at 100mg/kg body weight. Following confirmation of hyperglycaemia, groups I and II were treated with the extract at 1.32 and 2.64g/kg body weight for three consecutive days. After the last treatment, rabbits were fasted for 12 hours and bled at 0, 2, 6 and 24 hours. Serum glucose levels were determined by the glucose oxidase method and cholesterol levels by Liebermann-Buchard method. The results showed statistically significant decreases (P<0.05) in glucose levels at 0 and 2 hours, though there was an increase at 6 and 24 hours. Cholesterol levels decreased at 0, 2, 6 and 24 hours,but not significantly (P>0.05), when compared to control group III. Aqueous leaf extract of the mistletoe (an epiphyte of lemon trees) may be recommended for frequent consumption in the management of insulin-dependent diabetes.

Keywords: Mistletoe Extract, Glucose, Alloxan-Induced Diabetic Rabbits

Journal of Medical Laboratory Sciences Vol. 14 (1) 2005: pp. 28-32