Assessment of high sensitivity C-reactive Protein (HS-CRP) and total antioxidant status in patients with chronic kidney disease, diabetes and hypertension

Abstract

The levels of high sensitivity C-reactive protein (hs-CRP) and total  antioxidant capacity (TAC) and its relationship with other risk factors like blood pressure and anthropometric measurements were assessed. A total of 180 patients (90 controls, 90 patients (45 males; 45 females respectively) aged 18-76years old, diagnosed as having chronic kidney disease, diabetes and hypertension, but clinically stable were recruited from University of Benin Teaching Hospital. The controls were apparently healthy individuals. Anthropometric measurements were carried out (weight and height) to calculate the Body mass index (BMI). Serum samples were
collected for hs- CRP and TAC assays. The BMI was significantly higher P< (0.05) in hypertensive and diabetic patients but was normal in CKD (Chronic kidney disease) patients. Blood pressure was increased in CKD patients. Biochemical results revealed that CRP levels were significantly higher P < (0.05) while TAC levels were reduced in all the patients   compared with controls. There was no correlation P .0.05 between CRP and BMI but TAC was negatively correlated with CRP in CKD patients. However, in diabetic patients, CRP correlated positively with BMI and blood pressure while TAC correlated negatively with CRP. In conclusion, we recommend these biomarkers as adjuvant in the management of these diseases.