Rosai-Dorfman Disease: A Diagnostic Albatross in a Female Patient with Bilateral Persistent Neck Masses. A Case Report

Abstract

RosaiDorfman disease (sinus histiocytosis with massive lymphadenopathy) is an uncommon benign and often self limiting lymphoproliferative disease of unknown aetiology which was first described by Rosai and Dorfman in 1969. It usually presents with a multiple progressive painless bilateral cervical lymphadenopathy, low grade fever, polyclonal hypergammaglobulinemia and raised erythrocyte sedimentation rate. Extranodal diseases are uncommon but have been documented. Due to the rarity of this condition, the diagnosis may not be suspected clinically and fine needle aspiration cytology of neck nodes may miss the diagnosis. In this study, we present a 24 year old female who presented with bilateral cervical lymphadenopathy and right breast lump since childhood.