Adenosine Deaminase Activities in Hyperlipidaemic Patients.

Abstract

Adenosine Deaminase Activities, markers of cellular-mediated immunity were studied in a group of hyperlipidaemic patients of hypercholestrol, HDL-cholesterol, and LDL- cholesterol. Total ADA activities in the patients of hypercholesterolemia, stood at 32.1+7iu/1, HDLcholesterol at 34.8+.5iu/1and LDL-cholesterol at 37.3+4iu/1,ADA activities were statistically significantly higher (P<0.001) in the test groups than in the control groups (10.7+3iu/1) respectively. Correlation of ADA activities in hypercholesterolemia, HDL-cholesterol and LDL-cholesterol and the control (at 0.01 level 2-tailed) was significant, with the highest correlation (r=0.932) between LDL-cholesterol and hypercholesterolemia patients. Investigations and treatments in metabolic disorders especially dysilpidemias should be approached from the immunological perspective and further researches are to be carried out on those factors that modulate endocrinological factors such as insulin, cytokins, leptons or corticosterone which might affect immune functions.

KeyWords. Adenosine Deaminase, Metabolic disorders, Hyperlipidaemia