Prolonged piperazine treatment has no deleterious effects on the heamatological indices of the rat

Abstract

Effects of sub-chronic treatment with piperazine citrate on the haematological indices were investigated in the rat. Piperazine did not seem to have any deleterious effect on any of the haematological parameters studied. The mean PCV values in the three groups that were treated with piperazine 30, 60 and 100mg/kg were found to be 33.20+1.02% (p=0.5439). 34.20+ 3.28% (p=0.5472) and 34+1.41% (p=0.3892) respectively. None of these was significantly different from the control mean value of 31.80+1.96%. The average total WBC per mm3 of the treated groups that received 30,60 and 100mg/kg were 2760+733.4, 2700+782.3 and 2300+547.7 respectively. Differences between these values and the average control value were also not statistically significant (p=0.7672; 0.8336 and 0.7288 respectively). For the platelet counts, the result obtained did not follow a particular pattern and the test groups again did not show ant statistically significant difference in value compared to the control group.