Mesure des biomarqueurs du risque cardio-vasculaire chez les sujets en surcharge pondérale [Measurement of biomarkers of cardiovascular risk in overweight subjects]

Abstract

Objective-Screening for cardiovascular risk is crucial, particularly in overweight patients. The aim of this study was to measure the correlation between levels of conventional cardiac enzymatic (CPK) markers Creatine Phospho Kinase, LDH Lactate dehydrogenase, ASAT Aspartate Amino Transferase and ALAT Alanine Amino Transferase) and body mass index, and to study their association with the reference marker, ultra-sensitive CRP and Liporprotein a in a series of cases.
Materials & Methods-Sixty-two subjects were included in a descriptive cross-sectional study, divided into two groups according to body mass index. The first group included volunteers of the same sex and age group (BMI ≥ 25 kg/m²) and the second
group normo-weight volunteers (BMI≤18.5 kg/m²). An analysis of CPK, LDH, ASAT, ALAT and Liporprotein a ) was performed for the entire study population, whileultra-sensitive CRP,l ipid abnormality exploration and atherogenicity index were assessed only in the overweight population.
Results-LDH and CPK levels were significantly higher in overweight subjects compared with normoweight subjects. Ultra-sensitive CRP showed a positive and significant correlation with ASAT (r = 0.356*, p = 0.046) and LDH (r = 0.370*, p = 0.037).
Conclusion-The results suggest that LDH could be a promising lead in the measurement of cardiovascular risk in overweight subjects.