Fibrodysplasia ossificans progressiva: a case report and literature review

Abstract

Introduction
Fibrodysplasia Ossificans Progressiva (FOP) is an extremely rare genetic disease characterized by heterotopic ossification of muscles and connective tissue occurring in relapses, which can lead to the creation of a real second skeleton. The rarity of this disease is responsible for a delay in diagnosis of several years. FOP is described mainly in young children; cases with a late onset are extremely rare.
Observation
We report a case of late-onset Fibrodysplasia Ossificans Progressiva and we discuss clinical, radiological and genetic aspects, as well as treatment and outcomes.