Molecular basis of our organism’s intolerance to lack of genetic material

Abstract

Chromosomal fragments deletions are very harmful. They are almost lethal even in the presence of a normal homologue. Autosomal monosomies are incompatible with survival. However, micro-deletions are less fatal but they often produce clinical syndromes With characteristic phenotypes. Thus, a question rises: why does our organism not tolerate the lack of genetic material? The present work, is a profound investigation on the molecular basis of the intolerance of our organism to the lack of genetic material. The subject under discussion has never been dealt with before. Up to now, no article had been published on this matter.