Synthesis, Cu(II) Schiff base complexation and structural annalysis of the ligand 4-{[2-(methoxycarbonyl) pyrrolidin-1-yl] methyl} benzoic acid

Abstract

A new proline based ligand was syn thesized by a convenient procedure. The ligand was characterized by 1 H NMR, 13 C NMR and IR spectroscopies. Copper (II) Schiff base complexes of 4 --{[2 --(methoxycarbonyl) pyrrolidin 1 yl] methyl} benzoic acid of this ligand were synthesized and characterized by the aforementioned spectroscopy techniques, i.e. 1 H NMR, 13 C NMR and IR. Moreover, its bactericidal activity was assessed through the determination of the minimum inhibitory concentration (MIC) values as well as the i nhibition zone diameter for gram po sitive bacteria, such as Staphylococcus aureus , and gram negative bacteria like Klebsiella pneumoniae, Citrobacter freundii, Salmonella typhi, Enterobacter cloacae (the two bacteria Citrobacter freundii and Salmonella typhi are very sensitive against this molecule unlike Enterobacter cloac ae bacteria which is resistant).