Formulation of an oral emulsion for the delivery of active substances contained in Atriplex halimus L. leaves

Abstract

This work focuses on the formulation of an oral emulsion for the vectorization of active substances contained in the leaf extract of A. halimus. In order to optimize the formulation parameters of the double emulsion, a complete factorial design of 9 experiments was used. Microscopic observation, which indicates a structure, composed of spherical droplets with well-delimited edges dispersed in the continuous phase. The size of the laser particles indicates average lipid droplet diameters of about 10 μm. Zeta potential values are greater than -30 mV, indicating the electrical stability of dispersed systems. The rheological study showed that viscosity is influenced by the amount of xanthan gum, oil and gum arabic. Storage stability at different temperatures showed that some formulations are more stable than others.