Examining the effects of hydro-alcoholic extract of Momordica charantia fruit on avoidance memory alterations in mice using step-through model

Abstract

Medicinal plants have been, and still are, of a particular value and importance for public health provision in terms of both treatment and prevention of diseases. Among the effects of such plants are the impacts on the memory and learning process. In this study, the effect of hydroalcoholic extract of Momordica charantia on the avoidance memory alterations was investigated in mice using the step-through model. The hydroalcoholic extract of the soaked plant was administered to the mice at doses of 10, 25, 50, 100, and 200 mg/kg by gavage (intragastric tube) method. In comparison with the control group receiving only drinking water, the highest memory improvement was observed at a dose of 25 mg/kg. The results of interferential intraperitoneal administration of scopolamine and the extract gavage at a dose of 25 mg/kg indicated the ability to restore scopolamine-induced memory corruption by the total extract of M. charantia.