Synthesis, characterization, antibacterial and toxicological studies of heteroleptic acetylsalicylic acid and anthranilic acid metal complexes

Abstract

This present study aims at evauating the antibacterial, analgesic, and toxicologic al activities of new metals [Ni(II), Cu(II), Cd(II), and Zn(II)] complexes deri v ed from acetylsalicylic acid and anthranilic acid via refluxing method in a 1:1:1 stoichiometry ratio. Characterization was executed using melting point, molar conductance, infrared and ultraviolet visible spectroscopies . The antibacterial activities were investigated by the agar well diffusion method. The toxicological effect of the test compounds in serum and kidney homogenates of Wister rats was investigated. The screened complexes showed better antibacterial activities than their free ligands. The result of the analysis indicated that acetylsalicylic acid possessed a good significant analgesic activity, while toxicological studies confirmed that the complexes were toxic at the level of administered dosage.