Neutrophil to lymphocyte ratio correlate with syntax score in patients with non st elevation acute coronary syndrome

Abstract

Introduction: In this study we aimed to investigate the correlation between the neutrophil to lymphocyte ratio (NLR) and severity of coronary artery disease (CAD) in patients with Non ST elevation acute Coronary Syndrome (NSTE-ACS) using the SYNTAX score (SXscore).

Method: A total of 150 patients with NSTE-ACS who underwent coronary angiography were enrolled in the study. NLR was measured for all patients at presentation. The study population was then divided into 3 tertiles based on the SYNTAX trial results (1). The low syntax group (n = 25) was defined as those with an SXscore ≤ 22, the intermediate syntax group (n = 78) was defined as an SXscore ≥ 23 and < 33, and the high syntax group (n = 47) as those with an SXscore ≥ 33.

Result: NLR was significantly lower in patients with a low SXscore compared to patients with an intermediate SXscore or high SXscore (2.4 ± 2 to 4.8 ± 2 and 6.9 ± 3, P < 0.001). Linear regression analysis revealed that NLR (coefficient β = 0.470, 95%CI: 1.273-1.935, P < 0.001) was significantly associated with the SXscore in patients with NSTE-ACS.

Conclusion: Our results indicate that NLR is independently associated with the severity of CAD in patients with NSTE-ACS.