Effects of luteolin on intra peritoneal adhesion bands in rat

Abstract

Intraperitoneal adhesion is consequences of surgery in the abdomen and result in infertility, intestinal obstruction and pelvic pain. Luteolin (LUT) is a natural product that has antiinflammatory, anti-oxidant, anti-angiogenic effects and its effects were evaluated as anti-adhesive in animal model. 30 male rats assigned in to 5 groups (6 animals in each group) of LUT 10, 25 and 50 mg/kg and normal saline as a control group and intact animals. Animal anesthetized and peritoneal injury was conducted and seven days following to surgery, they scarified. Microscopic, macroscopic, lipid peroxidation changes and TNF-α plasma concentration were evaluated. LUT reduced microscopic and macroscopic injury and lipid peroxidation significantly. Plasma concentrations of TNF-α didn’t show any changes. LUT reduces lipid peroxidation, adhesion band formation in microscopic and macroscopic scale but no change in the serum levels of TNFalpha.

Keywords: Luteolin; Adhesion Bands; TNF-α; Lipid Peroxidation.