Effect Of Artesunate On The Nissl Bodies Of The Cerebellum Of Wistar Rats

Abstract

The study was to assess the effect of the administration of different doses of artesunate on the Nissl bodies of the cerebellum of Wistar rats. Twenty adult albino Wistar rats weighing between 160-180g were equally assigned into four groups (A, B, C and D). Group A served as the control that received distilled water, while groups B, C and D were the experimental groups. Groups B and C received 2.86mg/kg and 5.71mg/kg of artesunate respectively for three days, while group D received 2.86mg/kg of artesunate for six days. Twelve hours after the last administration the animals were sacrificed. There was reduced staining intensity of Nissl
bodies in groups B, C and D compared to the control. The reduction in staining was more in groups C and D especially in the granular and Purkinje cortical layers. These results revealed that artesunate cause reduced
Nissl bodies of the cerebellum of Wistar rats, and these reductions were dose and time dependent.