Effects Of Chloroquine On Some Visceral Organs In The Rabbit: Histopathological Perspective

Abstract

The histopathological changes caused by chloroquine phosphate in doses 5, 10 and 15mg/kg over 30, 60 and 90 days in the albino (n=10) and pigmented (n=22) rabbits, with mean weight value of 1.40 ± 0.44kg and mean age value of 9.0 ± 0.25 months were investigated in the College of Medicine, University of Nigeria, Enugu Campus. Histopathology results revealed linear, granular, bumpy stainable iron deposition on the wall of the myocardium. The lymphoid organs showed prominent necrosis, fibrosis and disappearance of lymhocytes. Histology of the rabbits\' duodenum also revealed marked mucosal ulcerationand loss of villi in all treated groups. Patients of malariasis are advised to consult their physicians for drug prescription and proper guidance in chloroquine consumption to avert the toxic consequences of frequent and indiscriminate chloroquine ingestion.


Key words: Heart, duodenum, lymphoid organ, ulceration, necrosis, histology

Journal of Experimental and Clinical Anatomy Vol. 4 (1) 2005: 50-54