Acute Toxicological Effects of Crude Oil On Haematological And Biochemical Parameters In Guinea Pigs

Abstract

The acute toxicological effects of Brass blend of crude oil on the haemoglobin concentration, and Liver functions in the Guinea pig were studied. 25 Guinea pigs divided into five animals per group were used for the study. They were divided into 5 groups. One group served as a control group, while the others received varying doses of crude oil intraperitoneally. After 24 hours of the administration, the following parameters were assayed: saerum Liver enzymes; aspartate transaminase, and alanine transaminase. Results show a doe dependent decrease in the haemoglobin concentration, while the bilrubin and enzyme levels in the blood increased in a dose dependent pattern, suggesting some degree of haematologic and hepatic pathology.


KEY WORDS: Crude oil, Biochemical parameters, Guinea pig.


J.Expt. & Clin. Anat. 2(2) 2003: 26-27