Effects of aqueous leaf extract of <i>Chromolaena odorata</i> on petrol-induced bronchiectasis in adult Wistar rats.

Abstract

BACKGROUND AND AIM: The most common cause of lung diseases among people with petrol-related occupations is petrol poisoning which has significant morbidity and mortality if left untreated. This study aimed to investigate the effects of aqueous leaf extract of Chromolaena odorata on petrol-induced bronchiectasis in the adult Wistar rats.

METHODOLOGY: Thirty adult Wistar rats weighing between 240 g and 270 g were divided into five (5) groups of six (6) rats per group. Animas in group A were placed on feed and water only. Animals in group B were exposed to 100 ml of petrol vapor via inhalation. Animals in group C received 500mg/kg body weight per day of Chromolaena odorata. Animals in group D were exposed to 100 ml of petrol vapor via inhalation and received 250mg/kg body weight per day of Chromolaena odorata. Animals in group E were exposed to 100 ml of petrol vapor via inhalation and received 500mg/kg body weight per day of Chromolaena odorata. The extract was administered for 30 consecutive days via an orogastric tube.

RESULTS: Groups A, C, D and E revealed normal histoarchitecture of the lung; normal alveoli, patent bronchiolar lumen and normal arteries. There were observable histological variations in the lung tissues of Group B rats which include bronchiolar destruction and widening, severe bronchiolar mucosal ulceration and vascular ulceration.

CONCLUSION: Based on the findings from this study, it was concluded that Chromolaena odorata had an ameliorative effect on petrol-induced bronchiectasis in Wistar rats.