Guanidine derivatives of Co(Ii), Ni(II), Cu(II) complexes and hepatitis activities studies

Abstract

This study determined hepatitis B and hepatitis C effectiveness of guanidine derivative, cobalt(II), nickel(II) and copper(II) complexes  using rats as test animal. Histopathological analysis was carried out. The derivatives demonstrated effectiveness at 2 mg kg-1 (w/w) for 5  ml kg-1 (v/w) concentration. Phosphonate compounds of benzothiazole demonstrated highest treatment, guanidine compouds of benzothiazole.were found to be next effective. The effectiveness trend was followed by phosphonate compounds of benzimidazole which  performed better than the benzimidazole compounds of the guanidine. The derivatives compete favourably with the vaccine contre  hepatitis recombinant standard which gave similar results of the analysis. The treatment properties of the derivatives therefore  demonstrated that benzimidazole compounds of the guanidine < phosphonate compounds of benzimidazole < guanidine compounds of  benzothiazole < phosphonate compounds of benzothiazole