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Haemostatic profile and determinants of Rheology in Nigerian pre-eclamptics
Abstract
Background; coagulation defects during pregnancy have over the years been known to contribute to morbidity and mortality.
Objective: to evaluate maternal rheology, and haemostatic profile in primigravidae with pre-eclampsia
Subjects and Methods: consecutive antenatal attendees were recruited into the study, comprising of pre-eclamptic primigravidae and apparently healthy normotensive primigravidae in second or third trimester.
Blood samples were obtained and analysed for coagulation profile [prothrombin time (PT). activated partial thromboplastin time (APTT)], rheological parameters [fibrinogen (PFC), haematocrit (Hct.), erythrocyte sedimentation rate (ESR) Plasma viscosity (PV)] ,and haemtological parameters using standard methods
Results: a total of 150 primigravidae were enrolled into the study, seventy-five with preeclampsia and 75 primigravidae, age and trimester matched, served as controls.
Mean systolic blood pressure, diastolic blood pressure,, body mass index and Hct. were significantly higher in preeclampsia compared with controls (p<0.0001), The platelet count was lower in the pre-eclamptic group. The fibrinogen, ESR, plasma viscosity, and blood viscosity were significantly higher in the preeclamptic group (p<0.0001). The PT was more prolonged in the preeclamptic group (p<0.001), APTT was more shortened in the pre-eclamptic group.
Conclusion: this study has further demonstrated a derangement in rheological determinants in pre-eclamsia. The prolonged prothrombin time observed in this group may indicate a quantitative or qualitative abnormality of factors of the extrinsic pathway. Further studies are recommended in Africans with pre-eclamsia to ascertain the role of factor VII in preeclampsia.
Objective: to evaluate maternal rheology, and haemostatic profile in primigravidae with pre-eclampsia
Subjects and Methods: consecutive antenatal attendees were recruited into the study, comprising of pre-eclamptic primigravidae and apparently healthy normotensive primigravidae in second or third trimester.
Blood samples were obtained and analysed for coagulation profile [prothrombin time (PT). activated partial thromboplastin time (APTT)], rheological parameters [fibrinogen (PFC), haematocrit (Hct.), erythrocyte sedimentation rate (ESR) Plasma viscosity (PV)] ,and haemtological parameters using standard methods
Results: a total of 150 primigravidae were enrolled into the study, seventy-five with preeclampsia and 75 primigravidae, age and trimester matched, served as controls.
Mean systolic blood pressure, diastolic blood pressure,, body mass index and Hct. were significantly higher in preeclampsia compared with controls (p<0.0001), The platelet count was lower in the pre-eclamptic group. The fibrinogen, ESR, plasma viscosity, and blood viscosity were significantly higher in the preeclamptic group (p<0.0001). The PT was more prolonged in the preeclamptic group (p<0.001), APTT was more shortened in the pre-eclamptic group.
Conclusion: this study has further demonstrated a derangement in rheological determinants in pre-eclamsia. The prolonged prothrombin time observed in this group may indicate a quantitative or qualitative abnormality of factors of the extrinsic pathway. Further studies are recommended in Africans with pre-eclamsia to ascertain the role of factor VII in preeclampsia.
