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Therapeutic Benefits of Maximum Androgen Blockade and Tolerability of Bicalutamide in Patients with Advanced Prostate Cancer
Abstract
Aim: To assess the therapeutic benefits of Maximum Androgen Blockade and the Tolerability of Bicalutamide, an oral non-steroidal anti-androgen in patients with advanced prostate cancer.
Patients and Methods: A total of forty-nine(49) male patients aged between 42 and 84 years with tumour grades T2, T3 and T4 were enrolled in a multi-centre clinical trial to receive bicalutamide 50mg daily following surgical castration. Patients were assessed for disease status, adverse events and quality of life.
Results: Thirty-three (33) patients completed the study and had therapy for 48 weeks, 90.9% of whom had complete response while the quality of life due to urinary symptoms was also markedly improved. The profile of adverse events was mild.
Conclusion: Bicalutamide given as a daily dose of 50mg in combination with surgical castration is a well tolerated therapy and has therapeutic benefits in African patients with advanced prostate cancer.
Key Words: Advanced Prostate Cancer, Surgical Castration, Bicalutamide, Tolerability, Thera-peutic Benefits, Maximum Androgen Blockade.
Journal of College of Medicine 2005: 9(2): 72-76
Patients and Methods: A total of forty-nine(49) male patients aged between 42 and 84 years with tumour grades T2, T3 and T4 were enrolled in a multi-centre clinical trial to receive bicalutamide 50mg daily following surgical castration. Patients were assessed for disease status, adverse events and quality of life.
Results: Thirty-three (33) patients completed the study and had therapy for 48 weeks, 90.9% of whom had complete response while the quality of life due to urinary symptoms was also markedly improved. The profile of adverse events was mild.
Conclusion: Bicalutamide given as a daily dose of 50mg in combination with surgical castration is a well tolerated therapy and has therapeutic benefits in African patients with advanced prostate cancer.
Key Words: Advanced Prostate Cancer, Surgical Castration, Bicalutamide, Tolerability, Thera-peutic Benefits, Maximum Androgen Blockade.
Journal of College of Medicine 2005: 9(2): 72-76
