Formulation d’une pommade antalgique et anti-inflammatoire à base d’un extrait hydroalcoolique des écorces de racines de Securidaca longepedunculata Fresen (Polygalaceae)

Abstract

Securidaca longepedunculata is a plant commonly used by African populations. Previous works have identified the main bioactive constituents; study the toxicity, analgesic, anti-inflammatory, antioxidant activities of the root barks. This work aims at developing an Improved Traditional Medicine (ITM) in ointment
based on the hydroethanolic extract of the root barks. The plant material was analyzed to determine the physicochemical parameters. The hydroethanolic extract was used to formulate ointments with shea butter. The quality parameters of the ointment were determined and the primary irritability was checked in albino rabbits. The local anti-inflammatory activity was evaluated against croton oil and xylem inflammation in mice. It exhibited stability at a temperature of 30°C and showed no skin irritation. It inhibited 27% of the inflammation to croton oil. Triterpenic saponins and antiradical constituents were the main chemical markers identified. These results and the existing data can be used for the development of “SECUDOL ointment”, an ITM against painful and inflammatory joint manifestations.