Reduced Formalin Nociceptive Responses In A Rat Model Of Post-Surgical Pain

Abstract

The responses to inflammatory pain were assessed in a rat model of post surgical pain using the formalin test. There were significantly reduced nociceptive responses in the second phase of the formalin test in both ipsilateral and contralateral limbs. The results either reflect reduced activity in mechanically insensitive afferents, AD and C fibers that mediate the second phase response, or a diffuse noxious inhibitory controls mechanism (DNIC).

Keywords: Pain, surgery, incision, formalin, DNIC

Journal of Biomedical Investigation Vol. 3 (2) 2005: pp. 12-15