Efficacy and safety profile of artesunate in different genotype patients with P. falciparum malaria.

Abstract

The efficacy and safety profile of anti- malaria, artesunate were studied in malaria patients of different genotype, AA, AS and SS.
A total number of 124 volunteer patients were divided according to their genotype group. 90(73%) volunteer patients were of AA genotype, 26(21%) volunteer patients were AS genotype and 8(6%) volunteer patients were of SS genotype. Artesunate has greatest efficacy of 100% in SS genotype patients and 98.9% cure rate in AA genotype patients and the least was 92.3% cure as in AS genotype patients. The failure rate was Zero in SS(Sickle cell disease) patients, 1.1% in AA patients and 6.7% in AS patients respectively. Artesunate produced very minor adverse effects in this study therefore artesunate is recommended as a drug of choice for treating uncomplicated malaria in SS patients and AA patients.


Keywords: Artesunate, Plasmodium Falciparium malaria, Genotype.

Journal of Biomedical Investigation Vol. 3 (1) 2005: pp. 31-33