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Changes in lipids and glucose concentration after voluntary wheel-exercise, high magnesium diet and magnesium fortification in rats
Abstract
In this study, the effects of voluntary exercise and magnesium fortification on lipid and glucose concentrations in growing rats were examined.
Thirty-six 5-week old male wistar rats were divided into 4 groups; CR, SR, EG and ESG (N=9) respectively.
500ppm of elemental magnesium as MgCl2 was provided in the drinking water of Mg- fortified groups. After one week of acclimatization and four weeks of Mg-fortification and/or exercise, the animals were fasted and sacrificed. Total magnesium concentration was similar in EG, ESG, and CR rats, but were all-lower than the concentration in SR rats (p<0.05). On the other hand, plasma ionized magnesium concentration was lower in EG and ESG compared with CR and SR rats (p<0.05). ESG rats had a significantly lower glucose concentration compared with EG rats (81.9+3.6 vs 87.5+4.3 mg/dl; P<0.05). Triglyceride concentration was also lower in ESG rats (103.4+12.6 mg/dl) than in EG (117.8+14.1 mg/dl), CR (134.8+23.7 mg/dl) and SR (133.1+25.8 mg/dl; P<0.05). Total cholesterol concentration (118.4+6.8 vs 126.0+8.0 mg/dl; P<0.05) was lower in ESG compared with SR, but HDLc concentrations in all the groups were similar.
The combination of exercise and magnesium fortification resulted in significant reduction in the concentrations of glucose, triglyceride and total cholesterol. This could prove to be a more effective way of control of metabolic indexes.
Key Word: Voluntary exercise-Magnesium fortification-Lipids-Glucose metabolism.
Journal of Biomedical Investigation Vol.1 2003: 40-47
Thirty-six 5-week old male wistar rats were divided into 4 groups; CR, SR, EG and ESG (N=9) respectively.
500ppm of elemental magnesium as MgCl2 was provided in the drinking water of Mg- fortified groups. After one week of acclimatization and four weeks of Mg-fortification and/or exercise, the animals were fasted and sacrificed. Total magnesium concentration was similar in EG, ESG, and CR rats, but were all-lower than the concentration in SR rats (p<0.05). On the other hand, plasma ionized magnesium concentration was lower in EG and ESG compared with CR and SR rats (p<0.05). ESG rats had a significantly lower glucose concentration compared with EG rats (81.9+3.6 vs 87.5+4.3 mg/dl; P<0.05). Triglyceride concentration was also lower in ESG rats (103.4+12.6 mg/dl) than in EG (117.8+14.1 mg/dl), CR (134.8+23.7 mg/dl) and SR (133.1+25.8 mg/dl; P<0.05). Total cholesterol concentration (118.4+6.8 vs 126.0+8.0 mg/dl; P<0.05) was lower in ESG compared with SR, but HDLc concentrations in all the groups were similar.
The combination of exercise and magnesium fortification resulted in significant reduction in the concentrations of glucose, triglyceride and total cholesterol. This could prove to be a more effective way of control of metabolic indexes.
Key Word: Voluntary exercise-Magnesium fortification-Lipids-Glucose metabolism.
Journal of Biomedical Investigation Vol.1 2003: 40-47
