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A Comparison of Measured and Predicted Haemoglobin Genotype in a Nigerian Population in Bonny, Rivers State, Nigeria
Abstract
Cellulose acetate electrophoresis technique has been used to estimate haemoglobin genotype and the predicted values from the estimate in accordance with the population genetics studies (Fleming and Lehman
1982) were evaluated in 850 subjects (386 males and 464 females) selected randomly from Bonny, in Rivers State, Nigeria of ages between 3 and 77 years. There was significant differences (P < 0.001) between the measured and the predicted haemoglobin genotype values suggesting that the predicted cannot be substituted for the measured. Two further haemoglobinopatheis, HbSC and HbCC were predicted to be the expected haemoglobin genotype of newborn into the population in the next decade suggesting that the incidence of abnormal haemoglobin in the population may arise from the complex interaction between the genetic constitution of the individual and some unidentified environmental factors.
1982) were evaluated in 850 subjects (386 males and 464 females) selected randomly from Bonny, in Rivers State, Nigeria of ages between 3 and 77 years. There was significant differences (P < 0.001) between the measured and the predicted haemoglobin genotype values suggesting that the predicted cannot be substituted for the measured. Two further haemoglobinopatheis, HbSC and HbCC were predicted to be the expected haemoglobin genotype of newborn into the population in the next decade suggesting that the incidence of abnormal haemoglobin in the population may arise from the complex interaction between the genetic constitution of the individual and some unidentified environmental factors.
