Halofantrine Hydrochloride (Halfan) Induced Toxicity of the Pancreas in Wistar Rats

Abstract

The toxicity of halofantrine hydrochloride to the pancreas of wistar rats (Rattus norvegicus) was studied using twenty five male wistar rats divided into five groups of five rats per group. Group A (control group) was given only clean water. Groups B. C. D and E received 0.7; 1.4; 2.1 and 2. 8g/kg Body not of halofantrine hydrochloride administered orally every six hours for three times (complete dose) respectively. The results showed Odema and swelling of pancreatic acini cells and obliteration of interstitial spaces. This toxicity effect was found to be dose dependent and significantly different from the normal integrity of the cells observed in the control experiment: The result underscored a possible toxic effect halofantrine when administered into man. Based on the result obtained, there was need for caution on the use of halfan in the treatment of malaria, particularly in cases of drug abuse. It is suggested that further studies are required to elucidate the implication of this toxicity to both the endocrine and exocrine functions of the pancreas