Bidirectional Communication Network: Exploring the Gut-Brain Axis as a Target for Ocimum Gratissimum Modulation in Neurodegenerative Disorder

Abstract

The intricate relationship between the gut and brain, known as the gut-brain axis, is increasingly recognized as a key player in neurological health and disease. Neurodegenerative disorders, such as Alzheimer's and Parkinson's, are often accompanied by gut dysbiosis and inflammation, suggesting a potential therapeutic avenue through modulation of this bidirectional communication network. This review explores the potential of Ocimum gratissimum, a plant with known anti-inflammatory and antioxidant properties, to influence the gut-brain axis and offer benefits in the context of neurodegenerative diseases. The study aim to synthesize current research investigating the effects of O. gratissimum and its bioactive compounds on gut microbiota composition, gut barrier integrity, and neuroinflammation, and to discuss the mechanistic pathways through which these interactions may impact neurodegenerative pathology. By reviewing the available evidence, the study highlight the promising, albeit preliminary, role of O. gratissimum as a potential therapeutic or adjunctive treatment strategy by targeting the gut-brain axis in the context of neurodegenerative disorders.