Liver and Kidney Biochemical Markers in Alloxan Induced Diabetic Wistar Rats: Effects of Buchholzia coriacea Seed Alcoholic Extract

Abstract

The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of various organs. Therefore, the objective of this paper was to assess the effects of wonderful kola (Buchholzia coriacea) on biochemical markers such as liver and kidney in alloxan induced diabetic Wistar rats using appropriate standard techniques. The result showed that Buchholzia coriacea seed extract caused significant (p<0.05) reduction in the levels of glucose. The liver function test revealed notable changes in the negative control group compared to the control group, including elevated levels of AST, ALT, ALP, and T.P (*p<0.05). Treatment with Metformin and the high dose of Wonderful Kola exhibited significant improvements in AST, ALT, and ALP levels compared to the negative control (#p<0.05), suggesting potential hepatoprotective effects. The  kidney function test, revealed notable difference In comparison to the control group, the negative control group showed significantly (p<0.05) elevated levels of Urea, Creatinine, K, Na, Cl, T.B, and C.B. Treatment with Metformin demonstrated a significant (p<0.05) decrease in Urea and Creatinine levels compared to the negative control. The low and high doses of Wonderful Kola resulted in significant (p<0.05) reductions in Urea, Creatinine, and T.B levels, with the high dose also significantly decreasing Na and Cl levels compared to the negative control. The methanoic extract of Buchholzia coriacea seed possess hypoglycemic properties and may therefore be beneficial in the management of diabetes mellitus at the above dosage and treatment period. Buchholzia coriacea especially at high doses exhibited protective effects on the liver and kidney biochemical markers in alloxan induced diabetic rats, highlighting its potential as a therapeutic agent.