Cardioprotective and Hematological Effects of Wonderful Kola (Buchholzia coriacea) in Wistar Rats Exposed to Aluminum Chloride-Induced Toxicity

Abstract

Aluminium pervades ecosystems, posing a nuanced risk of intoxication for both animal and human cohorts.  In this paper, cardioprotective and haematological effects of wonderful kola (Buchholzia coriacea) in Wistar rats exposed to aluminum chloride-induced toxicity was investigated by different methods including haematological analysis revealed significant decreases in PCV, HB, RBC, and PLT, with increased WBC in the aluminum chloride-induced group, indicating hematological toxicity (p < 0.05). Vitamin C partially restored parameters, while both low and high doses of Wonderful Kola extract showed positive effects, suggesting potential protection against aluminum chloride-induced toxicity (p < 0.05). Histological assessment demonstrated severe inflammation in the aluminum chloride-induced group, partial protection with vitamin C, and potential protective effects with Wonderful Kola, especially at higher doses. Wonderful Kola extract exhibited protective effects on cardiac tissue histology in aluminum chloride-induced toxicity, highlighting its potential as a therapeutic agent. These results contribute to the understanding of the potential therapeutic benefits of natural products in mitigating cardiovascular diseases. Further research on natural remedies for cardiovascular diseases is warranted, and caution should be exercised when considering treatments that may have detrimental effects on cardiac structure.