Histological and Toxicity Studies on Extracts of Stachytarpheta Jamaicensis on Liver, Kidney, Lungs and Heart of an Animal Models (Albino Rats)

Abstract

The objective of this study was to investigate the histological and toxicity studies on extracts of Stachytarpheta Jamaicensis on liver, kidney, lungs and heart of an animal models (Albino Rats) using appropriate standard methods. The results of the acute toxicity study showed that the LD50 values for all extracts were higher than 5000 mg/kg, as there were no signs of illness or death. The sub-acute toxicity investigations demonstrated that there were no adverse effects observed in the haematological, biochemical, and histological parameters of the blood and vital organs, respectively. Nevertheless, a notable disparity (p > 0.05) was detected in the relative weights of organs and body weights when comparing the high dose of 2000 mg/kg to the control group. This study thus provides novel evidence that the oral administration of aqueous and ethanol extracts derived from the leaf and root of Stachytarpheta jamaicensis at low to medium doses over a period of 21 days does not induce any harmful effects.